Project Open FlyWe created open fly as a an experimental community resource site In honor of Drosophila Information Service. We are committed to contributing to the wealth of resources. Currently working to develop more inSITE lines. We have an army of undergraduates We are open to collaboration. Got a screen idea?
MIT Open Courseware
For us the fly doubles as a simplified mouse and a highly sophisticated organ culture system. Working with the fly enables us to perform large scale screens in vivo not possible in traditional mammals, for both gene differences and directly for drugs. This cartoon shows the growth of a tumor when injected into a wild type host fly.
All Gal4 Stocks
In our recent PNAS paper we demonstrate that many FDA approved chemotherapeutics have an adverse effect on the microenvironment which in turn promotes stem cell hyperproliferation. This photo shows activation of STAT in daughter cells in response to treatment with certain chemotherapeutics.
We make models of tumorigenesis
by increasing and decreasing the expression of specific genes in specific cells of the intestine. The genes that we manipulate include oncogenes, miRNAs, tumor suppressors, and chromatin modifiers. The photo shows the effect of genetic manipulations leading to stem cell and daughter mutants.